Open Access Journal Article

Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells

by Chao Liu a ,  Qin Qin a  and  Hongliang Cong b,*
a
Institute of Cardiovascular Diseases, Chest Hospital, Tianjin University, Tianjin, 300222, China.
b
Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, 300222, China.
*
Author to whom correspondence should be addressed.
CI  2022 1(1):8; https://doi.org/10.58567/ci01010004
Received: 1 June 2022 / Accepted: 16 June 2022 / Published Online: 20 June 2022
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Abstract

Lung cancer is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers, and lung adenocarcinoma is the most common NSCLC. Most patients with lung cancer eventually lead to local and metastatic recurrence, including many patients who have completely removed the primary tumor during surgery and have no noticeable metastasis. There are two different deoxynucleotide triphosphate (dNTP) libraries in eukaryotic cells. The de novo synthesis of dNTPs in the cytoplasm is coordinated with the cell cycle and reaches a peak in the S phase, thereby providing deoxynucleotides for the replication of genomic DNA. In contrast, the mitochondrial pool of dNTPs is maintained through the mitochondrial deoxynucleoside rescue pathway throughout the cell cycle and is essential for mtDNA replication. Mitochondria are vital cell powers in assimilation and catabolism. Oxidative phosphorylation (OXPHOS) of mitochondria is essential for the self-renewal of cancer stem-like cells in lung cancer, glioblastoma and leukemia. Thymidine kinase 2 (TK2) and deoxyguanosine kinase (DGUOK) are two mitochondrial deoxynucleoside kinases, which are responsible for the transport of pyrimidine and purine deoxynucleoside in mitochondria. Apoptosis and autophagy are important processes that regulate cell proliferation and death in normal cells and cancer cells. Inducing cancer cell apoptosis and autophagy is an effective means to treat malignant tumors. This review discusses the research progress of the relationship between mitochondrial deoxyguanosine kinase and lung adenocarcinoma cell apoptosis and autophagy.

Keywords: Lung adenocarcinoma; Mitochondrial deoxyguanosine kinase; Apoptosis; Autophagy;
Copyright: © 2022 by Liu, Qin and Cong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Liu, C.; Qin, Q.; Cong, H. Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight, 2022, 1, 8. https://doi.org/10.58567/ci01010004
AMA Style
Liu C, Qin Q, Cong H. Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight; 2022, 1(1):8. https://doi.org/10.58567/ci01010004
Chicago/Turabian Style
Liu, Chao; Qin, Qin; Cong, Hongliang 2022. "Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells" Cancer Insight 1, no.1:8. https://doi.org/10.58567/ci01010004
APA style
Liu, C., Qin, Q., & Cong, H. (2022). Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight, 1(1), 8. https://doi.org/10.58567/ci01010004

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