Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.
Mukherjee, D.; Lahiri, D.; Nag, M. Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review. Cancer Insight, 2022, 1, 12. https://doi.org/10.58567/ci01020003
AMA Style
Mukherjee D, Lahiri D, Nag M. Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review. Cancer Insight; 2022, 1(2):12. https://doi.org/10.58567/ci01020003
Chicago/Turabian Style
Mukherjee, Dipro; Lahiri, Dibyajit; Nag, Moupriya 2022. "Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review" Cancer Insight 1, no.2:12. https://doi.org/10.58567/ci01020003
APA style
Mukherjee, D., Lahiri, D., & Nag, M. (2022). Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review. Cancer Insight, 1(2), 12. https://doi.org/10.58567/ci01020003
Article Metrics
Article Access Statistics
References
Urasa, M.; Darj, E. Knowledge of cervical cancer and screening practices of nurses at a regional hospital in Tanzania. Afr. Health Sci. 2011 , 11 , 48 –57. [ PubMed ]
Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R.L.; T orre, L.A.; Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018 , 68 , 394– 424. [ CrossRef ] [ PubMed ]
Kim, J.Y.; Byun, S.J.; Kim, Y.S.; Nam, J.- H. Disease courses in patients with residual tumor following concurrent chemoradiotherapy for locally advanced cervical cancer. Gynecol. Oncol. 2017 , 144, 34 –39. [ CrossRef ] [ PubMed ]
Hertlein, M.L.; Lenhard, M.; Kirschenhofer, A.; Kahlert, S.; Mayr, D.; Burges, A.; Friese, K. Cetuximab monotherapy in advanced cervical cancer: A retrospective study with five patients. Arch. Gynecol. Obstet. 2011 , 283, 109 –113. [ CrossRef ] [ PubMed ]
Kurtz, J.; Hardy -Bessard, A. -C.; Deslandres, M.; Lavau -Denes, S.; Largillier, R.; Roemer -Becuwe, C.; Weber, B.; Guillemet, C.;
Paraiso, D.; Pujade- Lauraine, E. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial. Gynecol. Oncol. 2009, 113, 16 –20. [ CrossRef ]
Herrera, F.G.; Chan, P.; Doll, C.; Milosevic, M.; Oza, A.; Syed, A.; Pintilie, M.; Levin, W.; Manchul, L.; Fyles, A. A pro spective phase I –II trial of the cyclooxygenase -2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. Int. J. Radiat. Oncol. 2007 , 67, 97 –103. [ CrossRef ] [ PubMed ] 9. Broutet, N.; Eckert, L.; Ullrich, A.; Bloem, P. Comprehe nsive Cervical Cancer Control: A Guide to Essential Practice; World Health Organ
Phuah, N.H.; Azmi, M.N.; Awang, K.; Nagoor, N.H. Down -Regulation of MicroRNA -210 Confers Sensitivity towards 1’S-1’Acetoxychavicol Acetate (ACA . in Cervical Cancer Cells by Targeting SMAD. Mol. Cells 2017 , 40, 291– 298. [CrossRef ] 23. Noh, S.; Choi, E.; Hwang, C.- H.; Jung, J.H.; Kim, S.-H.; Kim, B. Dietary Compounds for Targeting Prostate Cancer. Nutritients 2019 , 11 , 2401. [ CrossRef ] 24. Lowe, S.W.; Lin, A.W. Apoptosis in cancer. Carcinog. 2000 , 21 , 485– 495. [CrossRef ] 25. Li, F.-
Chen, X.; Song, L.; Hou, Y.; Li, F. Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells. Oncol. Rep. 2018 , 41 , 765 –778. [ CrossRef ] [ PubMed ] 37. Kuo, C. -Y.; Schelz, Z.; T óth, B.; Vasas, A.; Ocsovszki, I.; Chang, F.- R.; Hohmann, J.; Zupkó, I.; Wang, H.- C. Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines. Phytomedicine 2018 , 58 , 152770. [ CrossRef] [ PubMed
Lin, C. -L.; Lee, C.- H.; Chen, C. -M.; Cheng, C.- W.; Chen, P.-N.; Ying, T.-H.; Hsieh, Y. -H. Protodioscin induces apoptosis through ROS -mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer cells. Cell. Physiol. Biochem. 2018 , 46 , 322– 334. [CrossRef ] [ PubMed ] 49. Chatterjee, K.; Mukherjee, S.; Vanmanen, J.; Banerjee, P.; Fata, J.E. Dietary Polyphenols, Resveratrol and Pterostilbene Exhibit Antitumor Activity on an HPV E6 -Positive Cervical Ca
Dwarka, D.; Thaver, V.; Naidu, M.; Koorbanally, N.A.; Baijnath, A.H. In vitro chemo -preventative activity of strelitzia nicolai aril extract containing bilirubin. Afr. J. Tradit. Complement. Altern. Med. 2017 , 14, 147– 156. [CrossRef ] 61. Lee, K.M.; Lee, K.; Choi, Y.K.; Choi, Y.J.; Seo, H.S.; Ko, S.G. SH003 -induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Mol. Med. Rep. 2017 , 16 , 8237– 8244. [CrossRef ] 62. Dos Santos, K.M.; Gomes, I.N.F.; Silva -Oliveira
Esposito, T.; Sansone, F.; Franceschelli, S.; Del Gaudio, P.; Picerno, P.; Aquino, R.P.; Mencherini, T. Hazelnut (Corylus avellana L. . Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines. Int. J. Mol. Sci. 2017 , 18, 392. [ CrossRef] 73. Mannarreddy, P.; Denis, M.; Munireddy, D.; Pandurangan, R.; Thangavelu, K.P.; Venkatesan, K. Cytotoxic effect of Cyperus rotundus rhizome extract on human cancer cell lines. Biomed. Pharmacother. 2017, 95,
Zhang, L.; Zhou, J.; Qin, X.; Huang, H.; Nie, C. Astragaloside IV inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF -β 1-mediated PI3K and MAPK pathways. Oncol. Rep. 2019 , 41 , 2975– 2986. [CrossRef ] [ PubMed ] 87. Wang, Y.- Q.; Lu, J.-L.; Liang, Y.- R.; Li, Q.-S. Suppressive Effects of EGCG on Cervical Cancer. Molecules 2018 , 23, 2334. [ CrossRef ] [PubMed ] 88. Hung, C.- Y.; Lee, C.- H.; Chiou, H.- L.; Lin, C.-L.; Chen, P.- N.; Lin, M.-T.; Hsieh, Y.- H.; Chou, M
AL, A.O. Dietary supplements as a treatment for cervical cancer: A systematic review. Nutr. Hosp. 2013, 28 , 1770 –1780. 102. Wang, S.; Zheng, C.; Peng, C.; Zhang, H.; Jiang, Y.- P.; Han, T.; Qin, L.-P. Plants and cervical cancer: An overview. Expert Opin. Investig. Drugs 2013 , 22, 1133– 1156. [CrossRef ] 103. Roy, M.; Mukherjee, A.; Sarkar, R.; Mukherjee, S.; Biswas, J. In Search of Natural Remediation for Cervical Cancer. Anti -Cancer Agents Med. Chem. 2014 , 15 , 57 –65. [ CrossRef ]