Open Access Journal Article

Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications

by Xingru Zhao a,b ,  Qi An b,*  and  Jingwen Cai c,*
a
Beijing CapitalBio Technology Co., Ltd, Beijing 101111, China
b
State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing 100084, China
c
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
*
Author to whom correspondence should be addressed.
CI  2022 1(2):14; https://doi.org/10.58567/ci01020005
Received: 2 December 2022 / Accepted: 15 December 2022 / Published Online: 22 December 2022
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Abstract

Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydroxides. It has a series of unique properties, such as high conductivity, metalloid properties, a variety of valence states and adjustable structure and so on. These advantages make it have great potential in biomedical applications, such as diagnostic imaging, disease therapy and drug/gene delivery. This review presents the latest research progress of TMS/TMP on tumor imaging, diagnosis and treatment. Here, we first illustrate the synthesis approaches and surface modification of TMS/TMP. Then, its emerging applications in tumor diagnosis and therapy are highlighted. Moreover, the challenges of TMS/TMP-mediated diagnosis/treat are provided and the prospective for this field are discussed.

Keywords: Transition metal sulfides; Transition metal phosphides; Nanomedicine; Drug delivery; Cancer diagnosis and therapy;
Copyright: © 2022 by Zhao, An and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Zhao, X.; An, Q.; Cai, J. Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications. Cancer Insight, 2022, 1, 14. https://doi.org/10.58567/ci01020005
AMA Style
Zhao X, An Q, Cai J. Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications. Cancer Insight; 2022, 1(2):14. https://doi.org/10.58567/ci01020005
Chicago/Turabian Style
Zhao, Xingru; An, Qi; Cai, Jingwen 2022. "Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications" Cancer Insight 1, no.2:14. https://doi.org/10.58567/ci01020005
APA style
Zhao, X., An, Q., & Cai, J. (2022). Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications. Cancer Insight, 1(2), 14. https://doi.org/10.58567/ci01020005

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  1. Li, L.; Chen, C.; Liu, H.; Fu, C.; Tan, L.; Wang, S.; Fu, S.; Liu, X.; Me ng, X.; Liu, H. Multifunctional Carbon -Silica Na nocapsules with Gold Core for Synergistic Photothermal and Chemo -Cancer Therapy under the Guidance of Bimodal Imaging. Adv. Funct. Mater. 2016 , 26 , 4252 -4261.
  2. Song, Y. Y.; Li, C.; Yang, X. Q.; An, J.; Cheng, K.; Xuan, Y.; Shi, X. M.; Gao, M. J.; Song, X. L.; Zhao, Y. D.; Chen, W. Graphene oxide coating core -shell silver sulfide@mesoporous silica for active targeted dual -mode imaging and chemo -photothermal synergistic therapy against tumors. J Mater Chem B 2018 , 6 , 4808 -4820.
  3. Durgadas, C. V.; Sreen ivasan, K.; Sharma, C. P. Bright blue emitting CuSe/ZnS/silica core/shell/shell quantum dots and their biocompatibility. Biomaterials 2012, 33 , 6420 -6429.
  4. Ma, B.; Wang, S.; Liu, F.; Zh ang, S.; Duan, J.; Li, Z.; Kong, Y.; Sang, Y.; Liu, H.; Bu, W.; Li, L. Self-Assembled Copper -Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic T h e r a p y. J. Am. Chem. Soc. 2019, 141 , 849 -857.
  5. Li, L.; Guan, Y.; Liu, H.; Hao, N.; Li u, T.; Meng, X.; Fu, C.; Li, Y.; Qu, Q.; Zha ng, Y.; Ji, S.; Chen, L.; Chen, D.; Tang, F. Silica nanorattle -doxorubicin- anchored mesenchymal stem cells for tumor -tropic therapy. ACS Nano 2011 , 5 , 7462 -70.
  6. Zhang, Y.; Zhao, N.; Qin, Y.; Wu, F.; Xu, Z.; La n, T.; Cheng, Z.; Zhao, P.; Liu, H. Affibod y-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors. Nanoscale 2018, 10 , 16581 -16590.
  7. Meng, Z.; Wei, F.; Ma, W.; Yu, N.; Wei, P.; Wang, Z.; Tan g, Y.; Chen, Z.; Wang, H.; Zhu, M. Design and Synthesis of “All -in- One” Multifunctional FeS2Nanoparticles for Magnetic Resonance and Near -Infrared
  8. Zhang, Y.; Zhang, Y.; Hong, G.; He, W.; Zhou, K.; Yang, K.; Li, F.; Chen, G.; Liu, Z.; Dai, H.; Wang, Q. Biodistribution, pharmacokinetics and toxicology of Ag2S near -infrared quantum dots in mice. Biomaterials 2013 , 34 , 3639 -46.
  9. Qu, A.; Xu, L.; Sun, M.; Liu, L.; Kuang, H.; Xu, C. Photoactive Hybri d AuNR-Pt@Ag2S Core -Satellite Nanostructures for Near -Infrared Quantitive Cell Imaging. Advanced Functional Materials 2017 , 27 .
  10. Yang, T.; Tang, Y.; Liu, L.; Lv, X.; Wang, Q.; Ke, H.; Deng, Y.; Yang, H.; Yang, X.; Liu, G.; Zhao, Y.; Chen, H. Size -Dependent Ag2S Nanodots for Second Near -Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy. ACS Nano 2017 , 11 , 1848 -1857.
  11. Wang, G.; Liu, J.; Zhu, L.; Ma, X.; Wang, X.; Yang, X.; Guo, Y .; Yang, L.; Lu, J. Self-Destruction o f Cancer Induced by Ag2 S Amorphous Nanodots. Small 2019, 15 , e1902945.
  12. Liu, T.; Chao, Y.; Gao, M.; Liang, C.; Chen, Q.; Song, G.; Cheng, L.; Liu, Z. Ultra -small MoS2 nanodots with rapid body clearance for phototh ermal cancer therapy. Nano Research 2016 , 9 , 3003 -3017.
  13. Meng, X.; Liu, Z.; Cao, Y.; Dai, W.; Zhang, K.; Dong, H.; Feng, X.; Zhang, X. Fabricating Aptamer -Conjugated PEGylated -MoS2 /Cu1.8 S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo -Photothermal Therapy of Cancer. Advanced Functional Materials 2017 , 27 .
  14. Wang, S.; Chen, Y.; Li, X.; Gao, W.; Zhang, L.; Liu, J.; Zheng, Y.; Chen, H.; Shi, J. Injectable 2D MoS2 - Integrated Dru g Delivering Implant for Highly Efficient NIR -Trigge red Synergistic Tumor Hyperthermia. Adv Mater 2015, 27 , 7117 -22.
  15. Chang, M.; Wang, M.; Wang, M.; Shu, M.; Ding, B.; Li, C.; Pang, M.; Cui, S.; Hou, Z.; Lin, J. A Multifunctional Cascade Bioreactor Based on Hollow
  16. Yang, G.; Gong, H.; Liu, T.; Sun, X.; Cheng , L.; Liu, Z. Two -dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging -guided therapy of cancer. Biomaterials 2015, 60 , 62 -71. 23 . Yong, Y.; Cheng, X.; Bao, T.; Zu, M.; Yan, L.; Yin, W.; Ge, C.; Wang , D.; Gu, Z.; Zhao, Y. Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual -Modal Image -Guided Photothermal/Radiotherapy Synergistic Therapy. ACS Nano 2015 , 9 , 1245
  17. Qin, M. Y.; Yang, X. Q.; Wang, K.; Zhang, X. S.; Song, J. T.; Yao, M. H.; Yan, D. M.; Liu, B.; Zhao, Y. D. In vivo cancer targeting and fluorescence -CT dual -mode imaging with nanoprobes based on silver sulfide quantum dots and iodinated oil. N anoscale 2015, 7 , 19484 -92. 37 . Liu, T.; W ang, C.; Gu, X.; Gong, H.; Cheng, L.; Shi, X.; Feng, L.; Sun, B.; Liu, Z. Drug delivery wit h PEGylated MoS2 nano -sheets for combined photothermal and chemotherapy of cancer. Adv Mater 2014 , 26 , 3433 -40.
  18. Wang, S.; Zhao, J .; Yang, H.; Wu, C.; Hu, F.; Chang, H.; Li, G.; Ma, D.; Zou, D.; Huang, M. Bottom -up synt hesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression. Acta Biomater 2017 , 58 , 442 -454. 52 . Ding, B.; Zheng, P.; Ma, P.; Lin, J. Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applicati ons. Adv Mater 2020, 32 , e1905823. 53 . Hong, G.; Robinson, J. T.; Zhang, Y.; Diao, S.; Antaris, A. L.; Wang, Q.; Dai, H. In vivo flu
  19. Jin, Q.; Liu, J.; Zhu, W.; Dong, Z.; Liu, Z.; Cheng, L. Album in-Assisted Synthesis of Ultrasmall FeS2 Nanodots for Imagi ng-Guided Photothermal Enhanced Photodynamic Therapy. ACS Appl Mater Interfaces 2018 , 10 , 332 -340. 67 . Yang, W.; Guo, W.; Le, W.; Lv, G.; Zhang, F.; Shi, L.; Wang, X.; Wang, J.; Wang, S.; Chang, J.; Zhang, B. Albumin- Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging -Guided Tumor -Targeted Photothermal Therapy. ACS N ano 2016 ,
  20. Liu, J.; Jin, L.; Wan g, Y.; Ding, X.; Zhang, S.; Song, S.; Wang, D.; Zhang, H. A New Co -P Nanocomposite with Ult rahigh Relaxivity for In Vivo Magnetic Resonance Imaging -Guided Tumor Eradication by Chemo/Photothermal Synergistic Therapy. Small 2018, 14 . 81 . Tang, Z.; Zhang, H .; Liu, Y.; Ni, D.; Zhang, H.; Zhan g, J.; Yao, Z.; He, M.; Shi, J.; Bu, W. Antiferromagneti c Pyrite as the Tumor Microen vironment-Mediated Nanoplatform for Self -Enhanced Tumor Imaging and T h e r a p y. Adv Mater 2
  21. Yang, D.; Chen , F.; He, S.; Shen, H.; Hu, Y.; Feng, N.; Wang, S.; Weng, L.; Luo, Z.; Wang, L. One -pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors. New Journal of Chemistry 2019, 43 , 13256 -13262. 96 . Kue, C. S.; Ka mkaew, A.; Lee, H. B.; Chung, L. Y.; Kiew, L. V.; Burgess, K. Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy PDT . . Mol Pharm 2015 , 1 2, 212 -22. 97 . Xu, J.; Gulzar, A.; Liu, Y.; Bi, H .; Gai
  22. Anas, A.; Akita, H.; Harashima, H.; Itoh, T.; Ishikawa, M.; Biju, V. Photosensitized breakage and damage of DNA by CdSe -ZnS quantum dots. J Phys Chem B 2008 , 112 , 10005 -11. 113 . Lin, G.; Chen , T. ; Zou, J.; Wang, Y.; Wang, X.; Li, J.; Huang, Q.; Fu, Z.; Zhao, Y.; Lin, M. C.; Xu, G.; Yong, K. T. Quantum Dots -siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Fr ont Pharmacol 2017, 8 , 182. 114 . Tian, Q.; H u, J.; Zhu, Y.; Zou, R.; Chen, Z.; Yang, S.; Li, R.; Su, Q.