Open Access Review

Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis

by Jincheng Wang a orcid ,  Jinyu Sun a orcid ,  Tao Qin a ,  Xiaohan Ren a ,  Jin Zhang b orcid  and  Xiaojie Lu a,*
a
Department of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University,Nanjing, Jiangsu, China
b
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, 39216, USA
*
Author to whom correspondence should be addressed.
CI  2023 2(1):16; https://doi.org/10.58567/ci02010002
Received: 22 March 2023 / Accepted: 22 May 2023 / Published Online: 14 June 2023
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Abstract

The stages of liver fibrosis can reflect the severity of chronic viral hepatitis and the probability of liver cancer. Biopsy is still regarded as the reference for staging fibrosis, but the invasive method is not suitable for first-line screening. In recent years, noninvasive methods for detecting virus-driven liver fibrosis have been developed rapidly, which mainly include biological (serum biomarkers indexes) and physical (imaging assessment of liver stiffness) strategies. In this review, we introduce these noninvasive methods, enumerate their diagnosis performances and discuss the role of ferroptosis. At last, we propose directions for future researches.

Keywords: Noninvasive; Liver fibrosis; Diagnostic tests; Serum biomarkers; Imaging techniques;
Copyright: © 2023 by Wang, Sun, Qin, Ren, Zhang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Funding

the Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province (YXJR202002,toJ.W)

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ACS Style
Wang, J.; Sun, J.; Qin, T.; Ren, X.; Zhang, J.; Lu, X. Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis. Cancer Insight, 2023, 2, 16. https://doi.org/10.58567/ci02010002
AMA Style
Wang J, Sun J, Qin T, Ren X, Zhang J, Lu X. Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis. Cancer Insight; 2023, 2(1):16. https://doi.org/10.58567/ci02010002
Chicago/Turabian Style
Wang, Jincheng; Sun, Jinyu; Qin, Tao; Ren, Xiaohan; Zhang, Jin; Lu, Xiaojie 2023. "Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis" Cancer Insight 2, no.1:16. https://doi.org/10.58567/ci02010002
APA style
Wang, J., Sun, J., Qin, T., Ren, X., Zhang, J., & Lu, X. (2023). Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis. Cancer Insight, 2(1), 16. https://doi.org/10.58567/ci02010002

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