Objective: The DSS was utilized to construct colitis model of mouse. The colitis mice were colonized with gut microbiota. The effects of gut microbial metabolites on colitis were studied. The mechanisms of gut microbial metabolites to improve intestinal immunity were also further explored. Methods: The male BALB/c mice were selected to construct colitis mouse model with DSS and colonized with gut microbiota. The content of short-chain fatty acids in intestinal metabolites of mice during modeling were detected with GC-MS. After the mice were sacrificed, the colon tissue was stained to observe the colitis in different groups of mice. The contents of IL-22 and IL-17 in colon tissue was determined with ELISA method. To study the mechanism of relieving colitis, qRT-PCR and western blotting were used to study the horizontal of Ffar2 gene and pSTAT3 and pAKT in colon tissue, respectively. The congenital lymphocytes were isolated and purified, and the migration ability of the congenital lymphocytes was examined by cell scratch plane migration test. Results: The colonization of the gut microbiota had significant effects on the contents of short-chain fatty acids in the intestinal metabolites of colitis mice, of which the effect on the content of acetic acid and butyric acid was more significant. The colonization of gut microbiota could effectively relieve colitis in mice and effectively promote the secretion of IL-22 in colon tissue. Studying the remission mechanism indicated that colonization of gut microbiota with colitis could effectively promote the expression of Ffar2 gene in colon tissue and increase the expression of pSTAT3 and pAKT protein. The migration ability of the lymphocyte was significantly upregulated in the model group compared with the other groups, demonstrating that DSS can effectively activate the lymphocyte; The migration of congenital lymphocyte in the experimental group was significantly alleviated than that in the model group, but it was up-regulated than that in the positive control group, and the colonic tissue of the positive control group was similar to that of the normal group. Conclusion: The short-chain fatty acids in the intestinal flora metabolites can promote the gene expression of the metabolite-sensitive receptor Ffar2. The effective combination of short-chain fatty acids and Ffar2 receptors can promote the phosphorylation of STAT3 and AKT proteins, effectively promote the secretion of IL-22 in intestinal ILC3 cells, alleviate colitis in mice, and thereby improve their intestinal immune function.

Green credit policy (GCP) relies on financial means to promote environmental governance. Whether it can achieve the goals of economic development and environmental protection, especially in the context of different institutional supplies, remains to be scientifically tested. Based on the implementation of China’s Green Credit Guidelines in 2012, this study uses panel data of Chinese companies from 2009 to 2019 to explore the influence of GCP on green technology innovation and the role of institutional supply in it. The results show that GCP is instrumental in promoting green innovation in heavily polluting enterprises, and the promotion effect is heterogeneous based on green patent types, firms’ ownership, and regional financial development levels. Further analysis finds that the supply of environmental protection systems by local governments can strengthen the green innovation effect of GCP. However, the institutional supply of innovation has not yet released a promotional effect. This paper finds that green credit can be used as an environmental governance tool and provides inspiration for local governments to issue environmental protection policies scientifically.

As the COVID-19 epidemic swept the world in early 2020, it is worth watching how it affects the total factor productivity of enterprises. Based on the theory of information asymmetry and the data of A-share listed companies from 2014 to 2021, this paper conducts an empirical study on the relationship between COVID-19 and the total factor productivity of enterprises. The results show that the impact of the COVID-19 epidemic can significantly reduce the total factor productivity of enterprises, and the conclusion is still true after a series of robustness tests. Taking the financing constraint as an intervening variable, it clearly reveals a transmission mechanism, that is to say, the impact of the COVID-19 epidemic exacerbates the financing constraint of the enterprise, thus it makes the total factor productivity of the enterprise reduce. It is further found that the above effects are more obvious for small and medium-sized enterprises and non-intelligent enterprises. Based on this, the government should implement some active economic development policies to create a free, relaxed and orderly market environment for enterprise financing. At the same time, enterprises should not only pay attention to digital and intelligent development, and transform into technology-intensive enterprises, but also strengthen the awareness of worry. Enterprises should store "more grain" for preparing for the cold winter.

Breast cancer, as a malignant tumor with easy metastasis and poor prognosis, threatens the health of women around the world. Increasing studies have shown that the Bcl-2 family of apoptosis-related proteins is often expressed abnormally in breast cancer. The Bcl-2 homology 3 (BH3) mimetic peptide can bind and neutralize Bcl-2, preventing its binding to the apoptosis "effector" proteins Bak and Bax, thereby promoting the apoptosis process. However, there is a lack of effective intracellular delivery system for BH3 to exert its biological activity. Therefore, this study utilized an activatable supercharged polypeptide (ASCP) tumor-targeted delivery platform based on pH and protease response to achieve the targeted release of BH3 at the tumor site. Ultimately, intracellular delivery of BH3 was achieved and induced apoptosis of breast tumor cells, preventing the development of breast cancer.

This study underscores the chronic issue of gender pay disparity that prevails across different STEM fields and educational qualification levels in Australia. Despite instances where women's incomes may align or even surpass men's, the broader pattern of inequality remains undeniable. The study advocates for targeted strategies to address gender pay gaps, particularly in fields like Engineering and Science, and emphasises the significance of cultivating inclusive work environments that recognise and reward contributions regardless of gender. This study serves as a critical call to action to rectify these inequities and promote a more balanced and equitable STEM landscape.

We extend the Shariah-compliant digital assets and Islamic Fintech literature through exploring the time-frequency associations between the volatility index (VIX) and cryptocurrencies (both Islamic and traditional). Employing wavelet-based technique, we find that Islamic cryptocurrencies demonstrate low or no coherency with stock market volatility compared to traditional cryptocurrencies (except Tether) during the whole time and frequency bands, highlighting the hedging capabilities of Islamic cryptocurrencies. Tether also serves the same against VIX, as there is a low or favorable link between these variables. Finally, our findings would be prolific to digital currency traders and investors in designing the portfolio strategies.

Gold has been traditionally well recognized as a safe heaven for financial markets. Lately, Bitcoin has been gradually considered as a popular alternative. Since the outbreak of COVID-19 in early 2020, it has become even more necessary and critical to examine the diversification capability of them to hedge financial risks associated with an unexpected crisis comparable to the pandemic. This paper hence employs the wavelet analysis, complemented by the multivariate DCC-GARCH approach, to measure the coherence of the gold and Bitcoin prices with six representative stock market indices, three for developed economies and three for emerging economies, all of which are heavily affected by the pandemic. To have a more balanced and comprehensive analysis, two-year data are used, spanning from 12th April 2019 to 15th April 2021, which covers approximately one year before and one year after the announcement of the COVID-19 pandemic. The results suggest that the returns of both gold and Bitcoin are generally not strongly correlated with the market returns of all six indices, particularly for short-term investment horizons. That is, investors in all six indices can benefit through gold, as well as Bitcoin, in terms of hedging. Meanwhile, compared with Bitcoin, gold shows to be less correlated with the indices, particularly for long-term investment horizons. The findings hence suggest that gold and Bitcoin offer diversification benefits to investors in the market indices during a crisis such as the COVID-19 pandemic, especially for short-term investment horizons. The study also reminds policymakers thinking beyond the pandemic about the future of the earth, including air pollution and health, for sustainable development of the whole world.

Understanding how academia and industry operate and relate to each other is core to improving the efficiency of the entrepreneurial ecosystem. Reason why, this paper focuses on whether university prestige has a homogeneous effect on university entrepreneurship. Specifically, whether the relationship between academic prestige and entrepreneurship varies according to the nature of the firm, digital or not, or according to the size of the entrepreneurial partner. To answer this question, this paper uses a negative binomial regression model with panel data with respect to the number of intellectual property (IP) licences granted by the university, using mainly data from the Higher Education Statistics Agency. The results suggest that although university prestige affects the number of IP licences granted, its effect ceases to be significant when the nature of the licences is digital. Moreover, we cannot claim that the influence of prestige is greater when the licencee is a small company.

Innovation has received a great attention in the creative industries literature. We propose in this study a bibliometric method to examine the literature on innovation in creative industries (ICI). A file of 656 manuscripts published on ICI between 1998 and 2022 was retrieved from the Web of Science Core Collection for analysis. The results highlight the evolution of study volume, authors, affiliated institutions and countries, author networks, keyword co-occurrences, and keyword networks. The study also includes a thematic map that highlights four types of research: driving themes (e.g., digital technology, cultural innovation, performing arts, product innovation, innovation management); core and cross-cutting themes (e.g., creativity, digitization, technology, copyright); emerging themes (e.g., gender, artificial intelligence, sustainability); and specialized and peripheral themes (e.g., gender, blockchain, digital music). We finally conclude by proposing future perspectives and a research agenda in this area.

Following the seminal paper on Optimum Currency Areas (OCA) by Mundell (1961) a wealth of literature has been published on the business cycles synchronisation and its main determinants. This work provides a systematic review of this research field both at country-level synchronization and regional level. The paper aims to evaluate the contribution of the related literature’s methodologies to the measurement of the business cycle and the estimation of the level of synchronization. The discussion of the collected papers is expected to substantially assist researchers, practitioners, and policy makers keen to employ themselves in the area of business cycles synchronisation.

Current societal challenges related to retirement planning, healthcare systems’ evolution and environmental changes require households to pay a closer attention to their personal finances. This in turns calls for the associated industry to transform and scale. To do so, the personal finance industry could potentially leverage artificial intelligence tools for which there has been increasing levels of chatter. However, there is, to my knowledge, little consensus on whether or not those tools are appropriate given the challenges ahead. The literature review at the heart of this article first suggests that the stream of personal finance where transformation is more than needed is the one pertaining to investments, rather than the ones associated to loans, insurances or payments. Second, the productivity levers fueling the transformation of this branch are yet more driven, as of today, by simple digitalization notions rather by the usage of A.I. instruments. Over the next couple of years, more attention should thus be paid to use/business cases associated to investment products and the digitalization of their distribution chain.

In this study, we examined the efficiency of cryptocurrencies Bitcoin (BTC), Ethereum (ETH), Litecoin (LTC), Ripple (XRP), DASH, EOS, and MONERO from March 1, 2018, to March 1, 2023. We separated the sample into four subperiods for this purpose: a Tranquil period that includes the period from March 1, 2018, to December 31, 2019; a First Wave that includes the year 2020; a Second Wave that includes the year 2021; and a fourth subperiod that includes Russia's invasion of Ukraine in 2022-2023. The results are mixed, with some cryptocurrencies exhibiting equilibrium and others exhibiting autocorrelation and predictability in their pricing. When the sample is divided into subperiods, most digital currencies have long memories in their returns during the Tranquil period, BTC, LTC, and XRP exhibit efficiency during the First Wave of the pandemic, while BTC, ETH, and MONERO indicate efficiency during the Second Wave. Most assessed digital currencies showed equilibrium by 2022, with the exception of ETH and MONERO, which exhibit long memories, and LTC, which demonstrates anti-persistence. These results hold significance for investors in these alternative markets, as they suggest that some cryptocurrencies may be more predictable and therefore potentially profitable, whereas others may require greater caution and risk management strategies.

Electricity price volatility in developing economies, particularly Nigeria, presents a significant challenge to sustainable development. In this paper, we examine the macroeconomic drivers of electricity prices (ELP) in Nigeria based on annual data spanning 1980-2022 and the autoregressive distributed lag (ARDL) procedure. Our model estimates the long-run and short-run impacts of population growth (PG), economic growth (GDP), crude oil price (COPR), and electricity consumption (ELC) on electricity prices (ELP). The empirical findings reveal a positive and long-run effect of PG on ELP, indicating that rising demand from a growing population increases electricity prices. In the short-run, ELC surprisingly co-moved with ELP, which may be attributable to price-sensitive demand within specific consumer segments or periods. Furthermore, GDP and COPR exert positive effects on ELP, indicating that economic growth drives energy consumption and prices, and the cost-driven impact of fossil fuel dependence in electricity generation. These findings shed light on the complex interplay of demographic, economic, and energy market-related forces driving electricity prices in Nigeria. Therefore, the paper proposes some policy suggestions based on the empirical findings.

Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have profound effects on gene expression and function, such as immune response, cell development. Despite this, the clinical effects of RMW interactive genes on these cancers remain largely unclear. A comprehensive analysis of the clinical impact of these epigenetic regulators in pan-cancer requires further comprehensive exploration. Here, we systematically profiled the molecular and clinical characteristics of 26 RMWs across 33 cancer types using multi-omics datasets and validated the expression level of some RMWs in various cancer lines. Our findings indicated that a majority of RMWs exhibited high expression in diverse cancer types, and this expression was found to be significantly associated with poor patient outcomes. In the genetic alterations, the amplification and mutation of RMWs were the dominant alteration events. Consequently, the RNA Modification Writer Score (RMW score) was established as a means to assess the risk of RMWs in pan-cancer. We found that 27 of 33 cancers had significantly higher scores compared with normal tissues, and it was significantly correlated with prognosis. We also evaluated their impact on the tumor microenvironment and the response to immunotherapy and targeted therapy. These findings verified the important role of RMWs in different aspects of cancer biology, and provided biomarkers and personalized therapeutic targets for cancer.

At present, global warming poses the greatest threat to the planet's ecosystem. China is the greatest CO2 emitter, expected to account for roughly 33% of overall emissions in 2021, and this has caused authorities to express significant concern in the most latest Paris accord, when they decided to cut global emissions to a particular level. In comparison, 55% of China's power in 2021 appears from coal. As a result, investigating the ecological elements that affect China's CO2 output is essential. This analysis utilizes the autoregressive distributed lag (ARDL) technique to investigate the relationships concerning fossil fuels, renewables, and economic growth from 1990 to 2021. According to the data, using fossil fuels to generate energy and increase GDP significantly increases CO2 emissions. Yet, the use of renewable energy reduces CO2 emissions both in the long run and in the short term. Overall, the outcomes imply that using renewable energy sources is key to reaching sustainable environmental goals and deters the usage of fossil fuels in the energy mix. This study suggests that China take into account empirical findings and undertake long-term initiatives to reduce carbon emissions in favor of sustainable environmental outcomes.

It's critical for environmental governance to understand the effectiveness of policy interventions as well as their working mechanisms. This paper focuses on the vehicle license plate-based management, a sort of policy intervention understudied in environmental governance literature. Specifically, we study the automobile purchase restriction (APR), a major method of license management to address urban air pollution and traffic congestion recently launched by the authorities of China. However, limited studies have quantified the environmental impact of such purchase restriction. Based on the panel data of PM2.5 concentration in 330 cities in China during 1998-2016, this study aims to explore the causal impact of Beijing automobile purchase restriction on air quality, using the regression control method and high-dimensional data regression of machine learning. The average PM2.5 concentration did not decrease but increased because of the purchase restriction. Over time, the deterioration effect on urban air quality will not alleviate. Besides, the restriction cannot enhance urban air quality by decreasing the increase of PM2.5. Despite excluding the impact of driving restriction, the purchase restriction markedly aggravate urban air quality. This paper has some policy implications for policymakers on the impact of urban vehicle license management with caution. Hence, it is essential to promote urban economy, production, and lifestyle to attain the win-win goal of air pollution control and urban development.

In his "The World’s smallest macroeconomic model” (Krugman (1999)), Paul Krugman argued that under the assumption of price rigidity, a shortage of money supply leads to underemployment or recession, so increasing money supply can eliminate underemployment and restore full employment. But, how do we increase the money supply? I will show that we need a government deficit to increase the money supply in order to restore full employment from recession. Also, I will show that in a growing economy, if people hold money, a government deficit is necessary to maintain full employment under constant price or inflation. A government deficit is not only effective in pulling the economy out of recession, it is even necessary for continued growth without inviting either recession or inflation. The government deficit in this paper represents the difference between government expenditures and government revenues. When the difference is positive, we say that the government has a deficit. This paper seeks to explore theoretically and normatively the role of government deficits in achieving and maintaining full employment in a growing economy without causing inflation, using a very simple model by Krugman.

Stock indexes are used as a barometer of economic health, and fluctuations in these markets can have a substantial influence on the economy. For example, the Covid-19 pandemic caused severe economic disruption, as reflected in stock market indexes. Similarly, Russia's invasion of Ukraine has geopolitical implications that might undermine global trade and economic stability, impacting stock market indexes. Considering these developments, the purpose of this article is to examine the co-movements of the stock markets of Austria (ATX), Poland (WIG), the Czech Republic (PX Prague), Hungary (BUX), Croatia (CROBEX), Serbia (BELEX 15), Romania (BET), and Slovenia (SBI TOP) from February 16, 2018, to February 15, 2023. To achieve the research objectives, the aim is to answer the following research question: i) Have the events of 2020 and 2022 accentuated the co-movements between the stock markets in Central Europe? The results show the presence of 21 shocks between markets (out of a potential 56) during the Tranquil subperiod, with the WIG stock index having a greater predictive influence on the behavior of its peers (4 shocks out of 7 possible). During the Stress subperiod, 45 shocks were confirmed (out of 56 possible). The markets that triggered the most market shocks (7 out of 7 possibilities) were BET, BUX, CROBEX, and SBI TOP. The research question was validated based on the conclusion supplied, as all markets increased their movements, showing a considerable effect of the 2020 and 2022 events on these markets.

This paper aims to investigate the impact of political promotion on the productivity of manufacturing firms using the database of Chinese industrial enterprises from 1998 to 2007. We found that the political promotion of officials had a negative impact on manufacturing firm productivity, and this impact varied according to the characteristics of officials and enterprises. In addition, there was an age "ceiling effect" among Chinese municipal officials. Further research showed that the regional level of rule of law mitigated the negative effect of political promotion on the productivity of manufacturing firms. Finally, this paper makes policy recommendations for improving the promotion mechanism of officials, enhancing regional legalization, and transforming government functions.

This paper examines the impact of COVID-19 on Small and medium-sized enterprises (SMEs) deposits across 13 African nations from 2016 to 2022, using a seven-year dataset and Ordinary Least Squares estimator. Notably, it uncovers a significant positive link between the pandemic and SMEs deposits, indicating heightened reserves amidst economic uncertainty, potentially driven by risk mitigation or government support. Associations between gross domestic product (GDP), inflation, unemployment, foreign direct investment (FDI), exchange rates, and SMEs deposits were evident, showcasing higher GDP aligning with increased deposits, while inflation and unemployment linked to reduced ones. FDI showed a positive influence, and exchange rate fluctuations notably affected SMEs deposits, especially for those in international trade. These findings emphasize policy reconsideration for crisis strategies supporting SMEs reserves during uncertainty and interventions addressing inflation, unemployment, and exchange rate risks. Future research exploring regional nuances and global comparisons could further enrich policymaking for resilient SMEs amid evolving economic landscapes.