Cancer treatment faces multiple challenges, including tumor heterogeneity, drug resistance, microenvironment influence, treatment side effects, and treatment cost. The heterogeneity of the tumor makes the effect of the same treatment vary in different patients, so the development of personalized treatment strategies is crucial. In addition, resistance of tumor cells to therapeutic drugs is a major challenge, and new strategies to overcome resistance are needed. As a cutting-edge field of science and technology, nanotechnology has brought great potential and opportunities for tumor treatment. Nanoparticle drug delivery systems improve drug efficacy and reduce side effects through precise targeted delivery and controlled release. Cell-membrane coated nanoparticles show great promise in tumor therapy. Nanoparticles coated with cell membranes have good biocompatibility, can reduce the obstacles of immune rejection and cell uptake, improve the accumulation and retention of drugs in tumor tissues, and have good drug delivery ability, drug stability and control release ability. This review discusses advances in the use of cell-membrane coated nanoparticles to target tumor drugs.

With the development of information technology and its application in environmental governance, the role of the internet in improving energy efficiency and reducing energy-saving potential (ESP) has attracted more attention. In this study, the slack-based model (SBM) and the unexpected model, along with the entropy method, were applied to measure China's energy-saving potential and internet development. Further, we empirically analyzed the direct effect, mediating effect, threshold effect, and regional heterogeneity of the internet on ESP. Our conclusion shows that there is a significant spatial correlation between internet penetration and ESP. Internet penetration has become an important tool for reducing ESP, but this effect shows regional heterogeneity. Human capital accumulation, financial development, and industrial upgrading are important influencing mechanisms, but indirect effects are weaker than direct effects. The impact of internet penetration on ESP is non-linear, and for improving human capital accumulation, financial development, and industrial upgrading, the role of internet popularization in energy conservation is more obvious.

Deposit dollarization in Turkey has been on the rise, reaching record levels in 2022. This was caused by the worsening macroeconomic fundamentals along with the transition to the presidential system in 2018 and the associated deviation from the monetary policy stance afterward. The unique case of Turkey presents an excellent natural experiment to explore the dynamics of deposit dollarization and how it is affected by the changes in the institutional structure as well as various social, economic, and financial shocks in a relatively short time. This study examines the time varying reactions of deposit dollarization for the period between 2013 and 2022 based on rolling window maximum entropy bootstrap estimates. Our findings reveal that all the model variables had significant and sometimes asymmetric effects on deposit dollarization during the different stages of this turbulent period. In particular, we observe diminishing effects of real exchange rate, policy credibility and consumer confidence over time. The findings provide ample new evidence regarding the dynamics of deposit dollarization in general, and how it is affected by loss of monetary policy credibility.

The impact of international tourism on emerging markets has been overwhelmingly beneficial. Despite the obvious benefits of tourism, it comes at a high price for the environment in the form of pollution. Brazil's annual tourist influx has the potential to boost economic development and damage the country's ecosystems. The objective of this investigation is to analyze, using time series data ranging from 1990 to 2019, the effects of tourism and economic growth (GDP) on carbon dioxide (CO₂) emissions in Brazil. The stationarity of the data was examined by employing unit root tests, and an autoregressive distributed lag (ARDL) technique was used to investigate the link between the factors, taking both the long- and the short-run into consideration. This research shows that there are long-term and short-term ties between Brazil's tourism industry, GDP, and CO₂ emissions. Yet, both tourism and economic expansion have had serious negative effects on Brazil's ecology. These results indicate that in order to maintain environmental quality in Brazil, policymakers need to pursue more eco-friendly economic expansion as well as environmentally conscious tourist regulations.

Financial development and industrial structure optimization are two-wheeled engines for promoting high-quality development, but the causal identification of the two is still poorly understood. This paper addresses this research gap by comprehensively analyzing the relationship between them. Regional economic growth is a necessary condition for achieving high-quality development. Taking China as an example, this study empirically examines the role of financial development and industrial structure optimization in high-quality development using the entropy method, fixed effects, mediation effects and instrumental variable regression. The study results show that (i) financial development has actively promoted regional economic growth. (ii) The driving effect on the central and western regions is greater than that on the eastern region. (iii) There are differences in the mediating effect of industrial structure optimization and rationalization between different levels of financial development and economic growth. (iv) In addition, the mediating effect of industrial structure optimization is larger in the eastern region than in the central and western regions. (v) The mediating effect of industrial structure rationalization is not obvious in the eastern region, but has a masking effect in the central and western regions. Our findings provide new strategies for financial development and industrial structure optimization in developing countries.

Numerous studies have explored the impact of family planning policies on income distribution, but the impact of policy relaxation remains largely unexplored. To address this gap, we investigate the effects of China's selective two-child policy, which was implemented in 2013, using provincial panel data from 2011 to 2016. Specifically, we employ a generalized difference-in-differences model to empirically analyze the impact and mechanism of the policy relaxation on residents' income distribution. Our findings are as follows. Firstly, the selective two-child policy has narrowed the income distribution gap. Secondly, male labor force participation, the urban-rural income gap, and disposable income serve as mechanisms through which the selective two-child policy affects income distribution. Thirdly, the robustness test confirms the robustness of our conclusions. Finally, we observe regional heterogeneity in the impact of the selective two-child policy on residents' income distribution. Specifically, the policy has had significant effects in the western and northeastern regions, but not in other regions. Overall, our results shed light on the impact of childbearing policies on income distribution, providing important insights for optimizing China's childbearing policies and promoting common prosperity.

Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have profound effects on gene expression and function, such as immune response, cell development. Despite this, the clinical effects of RMW interactive genes on these cancers remain largely unclear. A comprehensive analysis of the clinical impact of these epigenetic regulators in pan-cancer requires further comprehensive exploration. Here, we systematically profiled the molecular and clinical characteristics of 26 RMWs across 33 cancer types using multi-omics datasets and validated the expression level of some RMWs in various cancer lines. Our findings indicated that a majority of RMWs exhibited high expression in diverse cancer types, and this expression was found to be significantly associated with poor patient outcomes. In the genetic alterations, the amplification and mutation of RMWs were the dominant alteration events. Consequently, the RNA Modification Writer Score (RMW score) was established as a means to assess the risk of RMWs in pan-cancer. We found that 27 of 33 cancers had significantly higher scores compared with normal tissues, and it was significantly correlated with prognosis. We also evaluated their impact on the tumor microenvironment and the response to immunotherapy and targeted therapy. These findings verified the important role of RMWs in different aspects of cancer biology, and provided biomarkers and personalized therapeutic targets for cancer.

This study delves into the complex relationship between China's international trade and economic growth, specifically focusing on emission intensity and its environmental ramifications within the context of energy efficiency. The primary objective is to provide a comprehensive understanding of how China's international trade dynamics influence economic growth, emphasizing emission intensity and employing a model that considers the nonlinear impact of trade on output. Through this model, structural breakpoints are identified, revealing distinct outcomes for China amidst positive and negative shocks from 1972 to 2021. The study uncovers the dual nature of the energy sector, acting both as a source of environmental degradation and a potential avenue for positive change through increased efficiency. Complex interplays among economic activities, inflation, and investment on carbon intensity are revealed. Additionally, the varying effects of export volume on carbon emissions intensity across lag thresholds underscore the significance of global trade dynamics for environmental sustainability. The study concludes by emphasizing the importance of balancing economic prosperity with environmental responsibility, advocating for carefully balanced policies that foster sustainable growth. Recommendations include considering the dual nature of the energy sector and implementing policies promoting increased efficiency. Policymakers are urged to adopt growth models prioritizing environmental responsibility, balancing economic activities, inflation, and investment to mitigate carbon intensity while acknowledging the diverse effects of global trade dynamics on environmental sustainability.

Cancer is the leading cause of death in the world, throughout the global researches of cancer treatment, people have a deeper understanding of cancer, and the treatment methods are constantly breakthrough. Conventional surgery, chemotherapy and radiotherapy have serious adverse effects and patients' quality of life is not significantly improved. Now, photodynamic therapy, photothermal therapy andthermodynamic therapy based on nanotechnology and materials technology are booming, and the development of these novel cancer therapies and their combination therapies brings more possibilities for cancer treatment. This review summarizes the research progress of novel cancer therapies based on nano and material technology from the aspects of mechanism of action and therapeutic methods, hoping to provide reference for their clinical application.

As a reversible post-transcriptional modification, N6-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a subpopulation of cells with self-renewal ability and differentiation potential, have been regarded to be one of the roots of tumor occurrence, recurrence, and metastasis. Currently, numerous studies have demonstrated that m6A RNA modification is critically implicated in the regulation of CSCs stemness or the CSC-like traits of cancer cells. This review summarized the effects of m6A RNA modification-related enzymes and underlying mechanisms contributing to CSCs or cancer cell stemness, which may provide novel targets and research directions for the specifical elimination of CSCs or cancer cells with stemness.

This study considers the effects of disclosure conditions on firms' investment decisions when facing an identical competitor in multiple markets. Assuming that there are congestion costs between multiple investments to reduce marginal cost for each market, this study focuses on the cases where the disclosure conditions may differ by market. Like previous studies on single Cournot competition, these results show that firms invest more in the observable investment markets than in the unobservable markets under symmetric disclosure conditions. However, firms invest more in the unobservable market if there are asymmetric disclosure conditions.

The purpose of this research is to investigate how globalization affects innovation in Vietnam’s small and medium sized enterprises (SMEs). Utilizing Probit model and the data from Vietnam’s SMEs Survey during the period 2005-2015, the research examines the micro and macro effects of globalization on the innovation of these businesses. The main results show that at macro level, globalization is negatively correlated with innovation. However, at micro level, increasing competition pressure and knowledge transfer due to globalization are positively correlated with innovation of Vietnam’s SMEs.

China's carbon emission trading market has been formally established, but few studies have been conducted to analyze the impact of this policy on the regional urbanization level. Therefore, this paper evaluates whether the carbon trading pilot policy can enhance the regional urbanization level in China through the difference-in-differences method and analyzes the mediating role of industrial structure upgrading in this process. The results prove that the carbon trading market policy can accelerate the transformation and upgrading of industrial structure in the region so that it promotes the development of regional urbanization. Moreover, the effects of the policy are concentratedly manifested in the eastern region of China.

The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and specificity." Taxanes, a pivotal class of successful anti-cancer drugs, continue to serve as the linchpin of cancer treatment due to their efficacy across a spectrum of cancer types. Operating as broad-spectrum chemotherapeutic agents, taxanes exert cytotoxic effects on proliferative cancer cells by binding to and stabilizing microtubules, disrupting mitosis, inducing mitotic catastrophe, and resulting in cell death. The distinct proliferative nature of cancer cells, as opposed to less proliferative non-cancer cells, affords taxanes a measure of specificity and selectivity. Nevertheless, sporadic yet recurring evidence suggests that taxanes also operate through non-mitotic mechanisms. Taxanes' binding and stabilization of microtubules lead to micronucleation and subsequent cell death, impacting both mitotic and non-mitotic cells. Recent discoveries indicate that the flexible and weakened nuclear envelope of malignant cells renders them sensitive to taxane-mediated micronucleation and cell death during various phases of the cell cycle. Conversely, non-cancerous cells typically exhibit a more robust and sturdy nuclear envelope, rendering them more tolerant to taxane-induced nuclear envelope fragmentation and subsequent micronucleation and cell death. The expression levels of nuclear envelope structural proteins, particularly Lamin A/C, emerge as indicators of taxane sensitivity. This evolving understanding underscores that nuclear envelope malleability, in conjunction with a high proliferation rate, is a pivotal determinant of taxane specificity and selectivity against malignant cells. These insights necessitate reconsidering oncological strategies to augment taxane efficacy, overcome resistance, and mitigate side effects.

This study empirically examines the effect of corporate governance on the relation between CEO power and firm leverage. Results from OLS and industry fixed effects regressions show that CEO power is positively associated with firm leverage. However, this association is driven by the strength of corporate governance as powerful CEOs tend to choose higher levels of debt only when corporate governance is strong. When corporate governance is weak, CEO power does not seem to have any effect on firm leverage. Overall, results indicate that strong corporate governance mitigates the severity of manager-shareholder conflicts and induces powerful CEOs to choose higher leverage.

This paper empirically investigates the relation between firm performance in corporate social responsibility (CSR) and the need and likelihood of external financing to test the predictions of agency and stakeholder theories. Empirical results from Logit, Linear Probability Model, OLS and Firm fixed effects regressions indicate that CSR is negatively related to the likelihood and level of external financing. Further analysis indicates that CSR has a negative and significant effect on both net equity issued (NEI) and net debt issued (NDI), the two components of external financing. Overall, the empirical results support the predictions of agency theory.

We analyze the annual microdata of China's 100 commercial banks from 2007 to 2018 using the mediating effect analysis method, analyze the negative impact of economic policy uncertainty on the credit scale of commercial banks, and then verify the intermediary effects of the operational risks and short-term capital liquidity of commercial banks in the impact of economic policy uncertainty on the scale of commercial bank credit, separately. Moreover, we find that non-state-owned commercial banks, large-scale commercial banks, low-leverage commercial banks, and commercial banks with low profitability are more susceptible to economic policy uncertainty affecting commercial bank credit growth through short-term capital liquidity, and vice versa.

Based on the empirical data of 6110 listed export companies in China from 2010 to 2019, this paper studies the impact of China's economic policy uncertainty (EPU) index on the profitability of listed companies from the specific perspective of export companies, and analyzes the moderating effects of different factors on this impact. The results show that China's EPU index has a significant negative impact on the profitability of listed export companies, and the increase in R&D investment and wage returns will aggravate this negative impact. In addition, listed export enterprises with different enterprise characteristics have different responses to EPU. State-owned enterprises and enterprises located in coastal areas are relatively less negatively affected by EPU.

As an important part of Traditional Chinese Medicine (TCM) inspection, face diagnosis is significant in judging the rise and fall of viscera and essence and diagnosing and treating diseases. Cancer is a serious disease that endangers human life and health. Face diagnosis can play a great role in diagnosing and treating tumors, but this approach has not achieved the expected effects due to the lack of research. Herein, we summarized the research regarding facial expression, color, shape, and state, demonstrating that facial diagnosis is significant in diagnosing and treating tumors. We also propose that facial diagnosis must be combined with computer technology to realize the objectification of facial diagnosis as soon as possible to play a greater role in diagnosing and treating tumors.

The objective of this research is to investigate, using time series data ranging from 1992 to 2021, the effects of information and communication technologies (ICTs) and foreign direct investment (FDI) on economic growth (GDP) in India. The stationarity of the data was examined by employing unit root tests, and an autoregressive distributed lag (ARDL) technique was used to investigate the link between the factors, taking both the long- and the short-run into consideration. According to the findings, an increase of one percent in both ICT and FDI will result in an increase of 0.56% and 0.71% in GDP over the long term, in addition to an increase of 0.11% and 0.29% over the short term. The findings of the investigation are of particular significance to policymakers because they can be utilized to establish sensible policymaking for long-term economic success, in addition to advancing the ICT sector and boosting FDI.