This paper evaluates the fit-for-purpose of the monetary policy measures implemented by the Bank of Ghana in response to the COVID-19 pandemic. We examine the effectiveness of the BoG’s policy interventions in the context of vector autoregressions augmented with macroeconomic and financial indicators. We demonstrate that the BoG’s monetary policy measures have had nominal, real, and financial effects. The monetary interventions have been successful, as evidenced by the gradual reduction in the sovereign spread, improved financial stability, and increased real economic activity. Our findings suggest that balance sheet actions are less effective and should be moderated in the conduct of monetary policy in jurisdictions without zero lower bound constraints. However, the analysis indicates that in times of crisis, central banks should deploy both standard and non-standard tools to stabilize dysfunctional financial markets and avoid a deflationary spiral. The historical and variance decomposition of the data reveal that monetary policy shocks have historically made the largest contributions to the targeted macro-financial aggregates during the pandemic episodes.

In developing countries, the dependence on traditional biomass for domestic energy consumption is one of the major causes of deforestation and environmental poverty. This paper investigates the impact of women’s education on the probability of using Unsustainable Biomass Cooking Technologies (UBCT) as the household main fuel of cooking instead of clean energy. Combining data from four rounds of Nigeria DHS conducted between 2003 and 2018, we take advantage of a natural experiment, the implementation of Uni-versal Primary Education policies in 1970, to obtain an exogenous variation in women’s education levels. Using an instrumental variable approach to control for the endogeneity issues, we find that women with higher levels of education are less likely to use UBCT as their primary source of cooking. This result implies that environmental policies in developing countries should rely not only on income transfers policies as suggested in the literature but also on increasing women's human capital to reduce women’s dependence on unsustainable biomass cooking practices.

The paper focuses on younger online viewers’ motivation to watch video game live streaming on live streaming platforms. Unlike existing scholars, it analyses younger online viewers’ watching motivation through a positive perspective and draws on the Play-Others-Downtime theory (P-O-D theory) and the motivation theory to establish the research model. By analysing 397 samples based on the variance-based structural equation modelling and partial least squares path modelling (SEM-PLS), the results present that younger viewers’ entertainment, social and leisure purposes positively affect their watching motivation. Control variables (i.e., gender, education background, and income level) demonstrate insignificant effects across the model. Considering the influence of the COVID-19 pandemic, watching video game live streaming is essential entertainment and social activities for younger adults. Future studies should identify the positive impact of video game live streaming and guide younger viewers to participate appropriately in this activity.

Objective: The paper, specifically examines whether the recently formed Regional Comprehensive Economic Partnership (RCEP) can potentially facilitate minimising the constraints to renewable energy goods exports at the regional level in Asia. Data, Methodology and Findings: Using the panel data from 11 RCEP members from 2006 to 2014, this study has applied the ‘meta frontier stochastic gravity frontier’ methodology and confirms that the establishment of RCEP has the potential to improve trade in renewable energy commodities within the RCEP region. Policy Implications: The policy implication is that when countries work together, it will lead to enormous benefits for national, regional, and worldwide prospects of a more sustainable energy future. Practical Policy Implications: In terms of practical policy implications, the developed RCEP member countries should actively engage in promoting R&D activities and protecting intellectual property rights concerning renewable energy production, which are essential for countries to integrate with the world market and to lift the export frontiers of both the developed and developing RCEP member countries to reach the unrestricted export of renewable energy technology.

This paper examines the information content of selected US industries focusing on the dynamic linkages among these industries, the stock market and a number of fundamental variables. The period of investigation spans from January 1960 to December 2021. The empirical strategy includes several methodologies such as regressions, vector autoregressions and volatility models. The idea is to investigate the dynamic linkages among these series at both the mean and the volatility levels. The results point to significant industry returns’ explanatory power for many predictors of economic activity including the stock market. Further, time-varying analysis of the linkages among the industries and the stock market’s returns reveal that certain industries such as Oil and Financials provide consistent information leadership over other industries and across decades. Further, upon assessing the industry–market return volatility spillovers, it was found that a market risk–return profile may not always be economically significant and timely for investors. Finally, crises, financial or otherwise, affect industries but to differing degrees.

The Hospital Price Transparency Final Rule aims at reducing the cost of healthcare in the United States by making information about the prices of medical services more readily available to market participants. The economic rationale is that higher price transparency should reduce the level and the dispersion of prices by disincentivizing hospitals from charging higher prices than possible. Using data on 3789 prices for three diagnostic imaging procedures and on the compliance with the rule for 86 acute care hospitals in the Greater Los Angeles area, we test the hypothesis that price levels and price dispersion are lower among hospitals that are more compliant. We do not reject this hypothesis, although we do not observe strictly decreasing relationships in all analyses. Prices are lower at hospitals with high or medium compliance than at hospitals with low compliance, but there is not a clear difference between hospitals with high and hospitals with medium compliance. Prices are less dispersed among hospitals with high compliance than among hospitals with low compliance, but the evidence for hospitals with medium compliance is less clear. We conclude that high compliance with the Hospital Price Transparency Final Rule implies lower prices and less price dispersion among hospitals.

Influenced by traditional notions of solidarity, when a province’s planning can be highly aligned with that of the central government, the province is perceived to be more collective and thus able to receive financial or resource favors from the central government. This consistency, as is often the case, reflected in doing the same thing as the central government. This situation may lead governors to ignore local economic performance and thus reduce regional innovation efficiency, as in the case of China’s Great Leap Forward. Likewise, it is possible to get better resources (energy or capital) by demonstrating managerial submissiveness, thus improving the regional innovation efficiency. Therefore, to verify the relationship between imitative governance and regional innovation efficiency, we collected relevant data from 31 major provincial administrative units in China, calculated the degree of imitative governance between provincial government work reports and central government work reports through text similarity, as well as utilized the SBM-DEA model to evaluate regional innovation efficiency. Meanwhile, we provide a new explanation of the phenomenon from the perspective of resource inclination. Finally, the empirical results show that imitative governance promotes local innovation efficiency and is moderated by resource inclination.

The low-carbon city pilot is an important policy for promoting sustainable development and addressing climate change. The level of green technological innovation is a significant driving force for China's transition to high-quality development and the realization of carbon peaking and carbon neutrality goals. This essay takes the panel data of 30 provinces in China from 2008 to 2020 as the research sample, regards the number of urban green invention patent applications as a quantifiable indicator of the level of urban green technological innovation, and takes the policy of low-carbon city pilot as a quasi-natural experiment, and uses the difference-in-differences model to test the impact of low-carbon city pilot on the level of urban green technological innovation, and to investigate the mechanism of action within. The main conclusions are as follows: (1) The policy of low-carbon city pilot has an outstanding promotion effect on the level of urban technological innovation. (2) Using the mediating effect to analyze, it is found that the low-carbon city pilot policy can improve the level of urban green technological innovation through the development of green finance.

The signing of RCEP has created new opportunities for the development of China's export trade, and international logistics capacity is an important factor affecting the conduct of international trade. This paper qualitatively describes and analyzes the LPI index and its sub-indicators of RCEP member countries, and empirically investigates the impact of logistics performance level on China's export trade through an extended gravity model. The study shows that there are large differences in logistics performance levels among RCEP member countries, especially in South Asia, where the quality of logistics infrastructure and customs efficiency are the most lagging behind, which are the key factors pulling down the logistics performance index; the signing of RCEP has effectively promoted China's foreign trade level, but there are great differences in export amounts to different countries, and the logistics performance levels of importing countries and China's export trade are significant positive correlation, the improvement of logistics performance is conducive to promoting China's export trade to RCEP member countries, and from the viewpoint of logistics links, the role of logistics infrastructure quality is the strongest, and the influence of cargo transportation timeliness is the weakest.

In the UK, a concern of prejudice, as well as a lack of gender identity and sexual orientation documentation, implies that LGBT persons mostly hidden to health-care providers. One of a review was carried out to examine primary literature on the psychological support requirements of LGBT cancer patients when receive treatment and after. Important findings: Key topics that have been mentioned include the negative impact on mental health, health care professional education and the absence of inclusive support groups, the pervasiveness of discriminatory practices within healthcare services. The research demonstrates how LGBT cancer patients are being failed by healthcare professionals in terms of psychological support, resulting in unmet requirements. There are some suggestions use to guarantee an LGBT inclusive atmosphere in cancer care, as well as the development of support programmes for LGBT people with cancer. Practical connotation: LGBT wellness and awareness education should be offered for HCP personnel. The registration and tracking of gender identity and sexual orientation is critical to ensuring that LGBT persons are not 'invisible' in cancer, radiation, and continued studies. LGBT cancer groups and services should be established, since information from the study indicated that LGBT individuals are actively seeking these services.

This research investigates the determinants of women's empowerment within households in a developing country. The investigation specifically focuses on the impact of employment and fertility, considering constraints imposed by family rules that play a pivotal role in shaping women's empowerment. The theoretical framework outlined in this study posits a simplistic model demonstrating that, within the prevailing family structure and household composition, earned income and fertility may bear significant relevance. Utilizing data extracted from the Pakistan Social and Living Standards Measurement Survey, we engage in estimating the level of female empowerment, operationalized as the extent of female authority over household expenditures. Notably, our empirical approach accounts for the endogeneity of employment and fertility through a two-stage estimation process. This involves leveraging information on family rules—representative of a family's cultural norms—pertaining to work and childbearing. Our empirical findings affirm the viability of family-specific rules as instruments to estimate and subsequently predict employment and fertility. Importantly, the evidence gleaned underscores the critical role of selecting valid threat options in theoretical analyses of women's empowerment.

This study examines the role of news sentiments in the GCC equity markets’ connectedness. We collected news titles for the period from 22nd June 2006 until 31st December 2020 from Gulf News, which is the most widely read English newspaper in the Arab World. We filter these news titles using a carefully designed list of keywords that capture public sentiment on matters related to financial markets. Next, we classify the news titles to compute the geographically distinguished sentiment indexes that allow for a detailed analysis of the source of news sentiment spillovers to compare the impact of domestic versus regional sentiments on the equity markets of GCC countries. Our quantile regression results reveal that equity markets in the GCC are most sensitive to news sentiments when underperforming. Moreover, our results from the connectedness approach suggest that the UAE equity markets are most influenced by domestic sentiments, whilst the KSA equity market is most influenced by regional sentiments from the other GCC countries. Mixed results are found for other countries. The time-varying component of this study also shows that the influence of news spillovers intensified during the major crises events, including the COVID-19 outbreak.

The vigorous development of the digital economy provides a new research perspective for alleviating local financial pressure. Based on the provincial panel data from 2013 to 2020, the mediating effect model and threshold regression model were used to explore the effect and mechanism of the digital economy on local fiscal pressure. The research shows that the digital economy has a significant alleviating effect on local financial pressure by increasing fiscal revenue, and this alleviating effect has a threshold effect on entrepreneurial activity. From the perspective of dimension, the alleviating effect of the digital economy development environment on local financial pressure is better than that of digital industrialization and industrial digitization. From a regional perspective, the digital economy has the most apparent impact on the western region. In addition, the quantile regression results show that with the increase in financial pressure, the easing effect of the digital economy shows an inverted U-shaped change. Therefore, in order to effectively alleviate the financial pressure on local governments, China should continue to promote the development of the digital economy, take multiple measures to increase entrepreneurial activity, and encourage various regions to implement differentiated digital economy development strategies according to local conditions.

Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.

The global financial crisis has affected all countries during the period 2007-2014. Tourist companies, especially in Italy, play a significant role in the economy of a country. The performance of tourism companies, and in particular hotels and travel agencies and tour operators, will be analysed in this paper, relative to the period of the crisis. The aim of this paper is to analyze profitability dynamics of the aforementioned tourist companies, to check whether they have suffered the effects of the global crisis. To this end, data from AIDA database relating to Italian companies in the sector were used. The profitability of these companies has been analyzed using the main profitability ratios, ROI and ROS ratios. An analysis of the trends and ANOVA of these ratios was carried out for the period 2007-2015. In this way, it has been verified whether the global crisis has affected profitability dynamics of hotels and travel agencies and tour operators in Italy. There is a parallelism in the trends of the main operators' indices in the three Italian macro-regions. The best performance is in the South, in a less developed economic context. The crisis has reduced the income indices in the first three years, even if the figure remains positive. Since 2012 there is a clear recovery, especially for hotels; intermediaries, on the other hand, suffer from competition from websites. However, the indices confirm the close relationship between travel agencies, tour operators and hotels. ROI mainly rewards first, while ROS intermediaries.

Cancer, a global health menace, continues to pose significant challenges in terms of incidence and mortality, necessitating innovative therapeutic strategies. Despite existing treatments, the limitations persist, prompting a quest for novel approaches. The emergence of immunotherapy marked a transformative era in solid tumor treatments, yet its efficacy is constrained by adverse effects. Concurrently, the integration of advanced technologies into cancer treatment explores the vast potential residing at the molecular level through gene analysis and manipulation. This review articulates the role of state-of-the-art genome editing technology, notably clustered regularly interspaced short palindromic repeats (CRISPR-Cas9), in overcoming the constraints of immunotherapy for cancers. Unveiling the intricacies of CRISPR-Cas9-mediated genome editing, the review introduces the formidable CRISPR toolbox. A spotlight is cast on the transformative impact of CRISPR-induced double-strand breaks (DSBs) on cancer immunotherapy, encompassing knockout and knock-in strategies. The utilization of CRISPR/Cas9 technology in pre-clinical cancer research has demonstrated notable success; however, its transition to the clinical setting remains in the nascent stages of development. This review aims to elucidate the fundamental aspects of CRISPR technology and offer a comprehensive survey of its existing applications while outlining its prospective role in the realm of cancer therapies. Through an exploration of CRISPR's mechanisms, current applications, and anticipated future potentials, this review provides valuable insights into the evolving landscape of CRISPR-based cancer treatment strategies.

The workforce participation rate, and hence the level of employment, for women in Pakistan is among the lowest in South Asia – standing at 25 percent in 2023. Conventional explanations attribute this to poor skills and cultural norms of families and society at large. Empirical work has established that low levels of education, and community attitudes regarding gender roles, hinder women's labor force participation. Ethnographic work suggests that household rules – family culture – on who makes decisions about opportunities for married women to work outside of the home for pay – profoundly impact female employment. This is due to the limited availability of data pertaining to explicit assessments of familial traditions that are pertinent to women's participation in the workforce beyond their domestic sphere. Drawing on data from the Pakistan Social and Living Standards Measurement Survey (PSLM): 2005-2006 – which provides information, from married women, on who in the family decides if they can work – we address this shortcoming in the literature. We find that in families where the decision lies clearly, and exclusively, in the hands of males, married women are 18-19 percent less likely to be employed than if the family culture is for married women – alone – to make this decision. Moreover, this is a much larger deterrent to work than poor education and residential location.

Carbon emissions trading is essential for reducing carbon emissions, and its role in regional carbon unlocking needs further clarification. This study uses the difference-in-differences (DID) model and synthetic control model (SCM) to evaluate the carbon unlocking effect of China’s six pilot carbon trading provinces. This study found that (1) carbon lock-in effects in China are mainly influenced by technology lock-in and fixed input lock-in; (2) each province’s overall carbon lock-in level presents a decreasing trend yearly, and the regional distribution presents characteristics of “low in the east and high in the west”; (3) carbon emissions trading pilot policies effectively promote the carbon unlocking effect in pilot regions overall, with Guangdong having the most significant unlocking effect. Conversely, Beijing, Hubei, Chongqing, and Shanghai also had different degrees of carbon unlocking. Finally, (4) an assessment of impact mechanisms indicates that technology and institutions have a significant mediating role in effectively promoting carbon unlocking under the carbon trading policy. Conversely, social behavior has an inverse effect, and fixed assets are not affected by the policy. This study demonstrates the carbon unlocking effect of carbon emissions trading and provides a quantitative reference for implementing carbon emissions trading policies and determining carbon unlocking paths.

In light of the events of 2020 and 2022, this study aims to examine the co-movements between the capital markets of the Netherlands (AEX), France (CAC 40), Germany (DAX 30), the United Kingdom (FTSE 100), Italy (FTSE MIB), Spain (IBEX 35), Russia (IMOEX), and spot prices of crude oil (WTI), silver (XAG), gold (XAU), and platinum (XPT) from January 1, 2018 to December 31, 2022. The purpose of this analysis is to answer the following research question: (i) Did the events of 2020 and 2022 increase the shocks between stock markets and WTI, XAG, XAU, and XPT prices? The findings indicate that time series do not follow a normal distribution and are stationary. In response to the question of investigation, we found that during the Tranquil period, it was possible to verify the existence of 28 causal relationships (out of 110 possibilities). During the stress period, there was a very significant increase in the number of causal relationships between the market pairs under analysis (62 causal relationships out of 110 possibilities), including a relative increase in the influence of commodities on capital markets and capital markets on commodities. These findings show that during the events of 2020 and 2022, capital markets and commodities significantly accentuated their co-movements among themselves, indicating that alternative markets such as WTI, XAG, XAU, and XPT do not provide safe-haven properties. These results have implications for portfolio diversification during times of global economic uncertainty.

The latent transforming growth factor-beta (TGF-β) binding protein 1 (LTBP1) has been implicated in various cellular processes, but its role in triple-negative breast cancer (TNBC) remains unclear. In this study, we investigated the impact of LTBP1 on TNBC progression and its underlying mechanisms. Analysis of online datasets revealed elevated LTBP1 mRNA expression in breast cancer tissues compared to normal adjacent tissues. Kaplan-Meier Plotter analysis indicated that high LTBP1 expression was negatively correlated with relapse-free survival (RFS), distant-metastasis free survival (DMFS), and overall survival (OS) of breast cancer patients. Additionally, LTBP1 mRNA levels were associated with chemotherapy resistance. Functional assays in TNBC cells demonstrated that LTBP1 knockdown suppressed cell proliferation, induced apoptosis, and attenuated migration and invasion. In vivo studies confirmed that LTBP1 knockdown inhibited tumor growth in a xenograft mouse model. Mechanistically, LTBP1 positively correlated with genes involved in signaling regulation and organelle organization, with significant associations to GTPase binding and the RhoA/ROCK pathway. LTBP1 knockdown reduced RhoA activity and phosphorylation of Myosin Light Chain 2 (MLC2), suggesting inhibition of the RhoA/ROCK signaling pathway. Moreover, activation of the RhoA/ROCK pathway partially rescued the effects of LTBP1 knockdown on TNBC cell proliferation, apoptosis, migration, and invasion. In conclusion, our findings suggest that LTBP1 promotes TNBC progression through activation of the RhoA/ROCK signaling pathway, highlighting its potential as a therapeutic target for TNBC.