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Articles ( Showing 1-20 of 23 items)
Searched for: [ Keywords: "Traditional Chinese medicine" ] clear all
Journal Article
Role of "facial diagnosis" objectification in tumor diagnosis and treatment
by Hao Zhang , Yuan Lu , Ya Qiao , Hang Song  and  Yongfu Zhu
Abstract
As an important part of Traditional Chinese Medicine (TCM) inspection, face diagnosis is significant in judging the rise and fall of viscera and essence and diagnosing and treating diseases. Cancer is a serious disease that endangers human life and health. Face diagnosis can play a great role in diagnosing and treating tumors, but this approach has not [...] Read more
Hit Affiliation:
Graduate School of Anhui University of traditional Chinese Medicine, Hefei, Anhui, China
Infrared and Low Temperature Plasma Key Laboratory of Anhui Province, NUDT, Hefei, Anhui, China
State Key Laboratory of Pulsed Power Laser Technology, NUDT, Hefei, Anhui, China
Anhui Fuxing Tech. Co., LTD., Suzhou, Anhui, China
School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China
The First Department of Oncology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
Hu Guojun Inheritance Talent Training Office, Hefei, Anhui, China

Journal Article
Exploring the Multi-level Interaction Mechanism between Drugs and Targets Based on Artificial Intelligence
by Yinfeng Yang  and  Jinghui Wang
Abstract
With the improvement of people's living standards and the increasing emphasis on health, new and higher demands are also placed on the medical industry. The diagnosis and treatment methods combining artificial intelligence and medicine are bound to receive more and more attention and promotion. At present, drug design is stepping into the era of artificial intelligence, and aca [...] Read more
Hit Affiliation:
School of Medical Informatics Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China
School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China

Journal Article
A prognostic aging-related lncRNA risk model correlates with the immune microenvironment in HCC
by Kun Mei , Zilu Chen , Qin Wang , Akbar Ali , Yan Huang  and  Luo Yi
Abstract
Background: Hepatocellular carcinoma (HCC) stands out as one of the most lethal cancers globally, given its complexity, recurrence following surgical resection, metastatic potential, and inherent heterogeneity. In recent years, researchers have systematically elucidated the significance of long non-coding RNA (lncRNA) in the initiation and progression of HCC. The intr [...] Read more
Hit Affiliation:
Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
Center for Molecular Imaging and Nuclear Medicine, Soochow University, School of Radiological & Interdisciplinary Sciences, Soochow University (RAD-X), Suzhou, China
Nanjing University of Chinese Medicine, Nanjing 210023, China
Department of Ultrasound, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210001, China
Department of Oncology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, China
Department of Oncology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China

Review
The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements
by Yi Wu , Yanqi Li , Tong Wu  and  Hongmei Yang
Abstract
Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom of cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles in pathophysiological mechanisms in cancer, which is attracting great attention. However, there are still controversies about whether [...] Read more
Hit Affiliation:
The Public Experimental Center, Changchun University of Chinese Medicine, Changchun 130117, China

Journal Article
Correlation between the immune microenvironment and bladder cancer based on a prognostic miRNA risk model
by Kun Mei , Zilu Chen , Le Huang , Joyce Wang  and  Yong Wei
Abstract
Background: Bladder cancer (BLCA), particularly invasive BLCA, has become a medical burden worldwide as it is associated with recurrence and easy metastasis. There are specific differences in the expression of various miRNAs in tumor and normal tissues. Hence, miRNAs can be used as biomarkers for tumor diagnosis and prognostic evaluation. The current study aimed to predict the [...] Read more
Hit Affiliation:
Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
Nanjing University of Chinese Medicine, Nanjing 210023, China
Department of Medicine, MetroWest Medical Center/Tufts University School of Medicine, Framingham, MA, USA
Department of Medicine, Division of Medical Oncology, Kansas University Medical Center, GI Oncology Working Group, Kansas City, KS, USA
Department of Urology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China

Review
Research progress of nanomedicine for tumor immunotherapy
by Xingyi Wan , Mengyan Jiang  and  Shriya Madan
Abstract
Cancer, a pervasive threat to human health, presents formidable challenges to traditional treatment approaches. Tumor immunotherapy has emerged as a promising strategy for combating malignancies by bolstering the body's immune response to thwart tumor metastasis and recurrence. Nonetheless, the intricacies of tumors, patient heterogeneity, and the presence of tumor-immunosuppre [...] Read more
Hit Affiliation:
Beijing Institute of Nanoenergy and Systems, University of Chinese Academy of Sciences, Beijing, China
College of Biological Resources and Environmental Engineering, Beijing University of Agriculture, Beijing, China

Journal Article
How Does Lncrna Regulation Impact Cancer Metastasis
by Abreto Devit Mancheng  and  Ugwemubwem Ossas
Abstract
Metastasis is the major cause of cancer-related mortality. Metastasis is a process through which cancer spreads from its initial location to other sections of the body. Cancer cells' epithelial-mesenchymal transition (EMT), anoikis resistance, cell migration, and angiogenesis are all well-known steps in this process. Investigating the molecular processes that govern cancer meta [...] Read more
Hit Affiliation:
Internal Medicine, Hopital du Mali, Bamako, Mali.

Review
Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements
by Chunfeng Liu  and  Lei Ren
Abstract
Ferroptosis, a recently identified form of programmed cell death, is characterized by the accumulation of lipid peroxidation, reactive oxygen species, and elevated free iron levels, involving the regulation of glutathione metabolism, iron metabolism, lipid metabolism, and oxidative stress biology. Tumor metastasis, a critical hallmark of malignancy and a key contributor to canc [...] Read more
Hit Affiliation:
Institute of Pathology, Faculty of Medicine, Ludwig Maximilians University of Munich, Munich, Germany.
Klinikum rechts der Isar, Faculty of Medicine, Technical University of Munich, Munich, Germany.

Journal Article
Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications
by Xingru Zhao , Qi An  and  Jingwen Cai
Abstract
Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydro [...] Read more
Hit Affiliation:
Beijing CapitalBio Technology Co., Ltd, Beijing 101111, China
State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing 100084, China
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Review
Overcoming MTDH and MTDH-SND1 complex: driver and potential therapeutic target of cancer
by Hao Shen , Jiayu Ding , Jiaying Ji , Binjian Jiang , Xiao Wang  and  Peng Yang
Abstract
Metadherin (MTDH), also known as LYRIC or AEG-1, is an oncogene that enhances tumor progression, metastasis, drug resistance, and immune escape in various cancers by modulating multiple oncogenic pathways, including NF-κB, PI3K/AKT, Wnt/β-catenin, MAPK, and AMPK. Due to the unknown of the complete structure of MTDH, the deep mechanisms of MTDH and selective inhibitor [...] Read more
Hit Affiliation:
State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China

Review
Reassessing specificity/selectivity of taxane-based chemotherapy
by Elizabeth R. Smith , Zheshen Li , Zhe-Sheng Chen  and  Xiang-Xi Xu
Abstract
The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and [...] Read more
Hit Affiliation:
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA

Journal Article
Comprehensive analyses reveal molecular and clinical characteristics of RNA modification writers across 32 cancer types
by Jiayu Ding , Hao Shen , Jiaying Ji , Jiaxing Li , Wenbin Kuang , Zhongrui Shi , Dawei Wang , Yuanyuan Chen , Didi Wan , Xiao Wang  and  Peng Yang
Abstract
Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have pr [...] Read more
Hit Affiliation:
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China
BGI College & Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou University, Zhengzhou 450052, China

Journal Article
Role of Natural Products in Combating Cancer
by Camilla Barreto  and  Alwjandra Jandus
Abstract
Alternative bio actively chemicals may be found in natural goods and traditional herb medications, but only a few plant-information formulations have been rigorously studied and verified for their potential as medicinal therapies. The study of plant-derived elements' immunomodulation capabilities and their ability as provoke the immune system as combat various elemental disorde [...] Read more

Review
Cell membrane-coated nanoparticles for cancer therapy
by Yasir Hameed , Mohsen Nabi-Afjadi , Yuan Gu  and  Long Wu
Abstract
Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanopar [...] Read more

Journal Article
Drug Transport via Nanocarrier for Liver Cancer Treatment
by Shafirah Hussein  and  Jaffri Ruben
Abstract
The requirement of having multiple nanocarriers (NCs) and active agents for improved therapy, imaging, and controlled release of medications efficiently in one platform has made the creation of therapeutics and theragnostic nanodrug delivery systems a difficult task for present researchers. Multiple drug resistance (MDR), a high clearance rate, severe side effects, undesirable [...] Read more

Journal Article
Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development
by Zhengdong Yuan , Yiwen Zhang , Xuena Yang  and  Hai Qin
Abstract
Breast cancer, as a malignant tumor with easy metastasis and poor prognosis, threatens the health of women around the world. Increasing studies have shown that the Bcl-2 family of apoptosis-related proteins is often expressed abnormally in breast cancer. The Bcl-2 homology 3 (BH3) mimetic peptide can bind and neutralize Bcl-2, preventing its binding to the apoptosis "effector" [...] Read more
Hit Affiliation:
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Department of Clinical Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 550014, China

Journal Article
Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells
by Chao Liu , Qin Qin  and  Hongliang Cong
Abstract
Lung cancer is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers, and lung adenocarcinoma is the most common NSCLC. Most patients with lung cancer eventually lead to local and metastatic recurrence, including many patients who have completely removed the primary tumor during surgery and have no noticeable m [...] Read more
Hit Affiliation:
Institute of Cardiovascular Diseases, Chest Hospital, Tianjin University, Tianjin, 300222, China.
Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, 300222, China.

Journal Article
The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression
by Haitao Chen , Huilong Li , Wanjin Shi , Hai Qin  and  Lufeng Zheng
Abstract
As a reversible post-transcriptional modification, N6-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a subpopulation of cells with self-renewal ability and differentiation potential, have been regarded to be one of the roots of tumor occurrence, recurrence, and metastasis. Currently, numerous studies have dem [...] Read more
Hit Affiliation:
School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China
Department of Clinical Laboratory, Guizhou Provincial Orthopedic Hospital, No. 206, Sixian Street, Baiyun District, Guiyang City, Guizhou Province, China

Review
E3 ubiquitin ligase-dependent regulatory mechanism of TRIM family in carcinogenesis
by Gui Zhang , Yunfang Zhang , Luxuan Chen , Langxia Liu  and  Xuejuan Gao
Abstract
Tripartite motif-containing (TRIM) proteins consist of over 80 proteins, the majority of which exhibit E3 ubiquitin ligase activity. E3 ligases have a critical role in various cellular processes by specifically recognizing and ubiquitinating substrate proteins to promote their proteasomal degradation or alter their activities. Numerous studies have indicated that TRIMs are invo [...] Read more
Hit Affiliation:
MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Department of Nephrology, Affiliated Huadu Hospital, Southern Medical University (People's Hospital of Huadu District), Guangzhou, China.

Review
Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
by Fatemeh Movahedi , Li Li  and  Zhi Ping Xu
Abstract
Cancer chemotherapy is generally associated with many severe adverse effects. Many cancer studies are currently focused on repurposing conventional non-toxic anti-parasite drugs for cancer treatment. Since cancer cells and parasites have many features in common, some anti-parasite drugs such as benzimidazoles have been recently found to possess the anti-cancer activity. Benzimi [...] Read more
Hit Affiliation:
Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen 518107, China