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Articles ( Showing 1-20 of 18 items)
Searched for: [ Keywords: "drug resistance" ] clear all
Review
Advances in the use of cell-membrane encapsulated nanoparticles to target tumor drugs
by Mengdie Feng  and  Yonghua Zheng
Abstract
Cancer treatment faces multiple challenges, including tumor heterogeneity, drug resistance, microenvironment influence, treatment side effects, and treatment cost. The heterogeneity of the tumor makes the effect of the same treatment vary in different patients, so the development of personalized treatment strategies is crucial. In addition, resistance of tumor cells to therapeu [...] Read more

Journal Article
Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation
by Suleyman ILHAN
Abstract
Although docetaxel treatment yields a high survival rate for prostate cancer (PCa), resistance eventually develops in many patients. Understanding the underlying mechanisms of docetaxel resistance is essential for improving treatment strategies. Cytokines, which play a role in cell signaling and immune responses, have been implicated in drug resistance mechanisms. The study rev [...] Read more

Journal Article
Drug Transport via Nanocarrier for Liver Cancer Treatment
by Shafirah Hussein  and  Jaffri Ruben
Abstract
The requirement of having multiple nanocarriers (NCs) and active agents for improved therapy, imaging, and controlled release of medications efficiently in one platform has made the creation of therapeutics and theragnostic nanodrug delivery systems a difficult task for present researchers. Multiple drug resistance (MDR), a high clearance rate, severe side effects, undesirable [...] Read more

Review
Overcoming MTDH and MTDH-SND1 complex: driver and potential therapeutic target of cancer
by Hao Shen , Jiayu Ding , Jiaying Ji , Binjian Jiang , Xiao Wang  and  Peng Yang
Abstract
Metadherin (MTDH), also known as LYRIC or AEG-1, is an oncogene that enhances tumor progression, metastasis, drug resistance, and immune escape in various cancers by modulating multiple oncogenic pathways, including NF-κB, PI3K/AKT, Wnt/β-catenin, MAPK, and AMPK. Due to the unknown of the complete structure of MTDH, the deep mechanisms of MTDH and selective inhibitor [...] Read more
Hit Affiliation:
State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China

Journal Article
Exploring the Multi-level Interaction Mechanism between Drugs and Targets Based on Artificial Intelligence
by Yinfeng Yang  and  Jinghui Wang
Abstract
With the improvement of people's living standards and the increasing emphasis on health, new and higher demands are also placed on the medical industry. The diagnosis and treatment methods combining artificial intelligence and medicine are bound to receive more and more attention and promotion. At present, drug design is stepping into the era of artificial intelligence, and aca [...] Read more

Review
Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
by Fatemeh Movahedi , Li Li  and  Zhi Ping Xu
Abstract
Cancer chemotherapy is generally associated with many severe adverse effects. Many cancer studies are currently focused on repurposing conventional non-toxic anti-parasite drugs for cancer treatment. Since cancer cells and parasites have many features in common, some anti-parasite drugs such as benzimidazoles have been recently found to possess the anti-cancer activity. Benzimi [...] Read more

Review
Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity
by Sindhu Ramesh , Peyton Johnson , Khalda Fadlalla , Austin Moore , Chung-Hui Huang , Kristy Berry , Yulia Y Maxuitenko , Xi Chen , Adam B Keeton , Gang Zhou  and  Gary Piazza
Abstract
Approximately 28 million individuals in the United States face the risk of developing precancerous colonic adenomas (polyps) and potentially progressing to colorectal cancer (CRC). While a promising strategy for CRC prevention involves pharmacological intervention, such as cancer chemoprevention or interception, currently, there are no FDA-approved drugs capable of preventing t [...] Read more
Hit Affiliation:
Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA

Letter
Getting high on the market: Stock price movements, drug abuse, and health implications
by Tomasz Piotr Wisniewski  and  Brendan John Lambe
Abstract
Using an international dataset, this letter finds that high stock returns are associated with increased death rates from drug use disorders. Although the out-of-pocket expenditure on healthcare also rises following a stock market surge, the net effect on life expectancy is significantly negative. [...] Read more

Review
Reassessing specificity/selectivity of taxane-based chemotherapy
by Elizabeth R. Smith , Zheshen Li , Zhe-Sheng Chen  and  Xiang-Xi Xu
Abstract
The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and [...] Read more

Review
Cell membrane-coated nanoparticles for cancer therapy
by Yasir Hameed , Mohsen Nabi-Afjadi , Yuan Gu  and  Long Wu
Abstract
Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanopar [...] Read more

Review
Research progress of nanomedicine for tumor immunotherapy
by Xingyi Wan , Mengyan Jiang  and  Shriya Madan
Abstract
Cancer, a pervasive threat to human health, presents formidable challenges to traditional treatment approaches. Tumor immunotherapy has emerged as a promising strategy for combating malignancies by bolstering the body's immune response to thwart tumor metastasis and recurrence. Nonetheless, the intricacies of tumors, patient heterogeneity, and the presence of tumor-immunosuppre [...] Read more

Journal Article
How Does Lncrna Regulation Impact Cancer Metastasis
by Abreto Devit Mancheng  and  Ugwemubwem Ossas
Abstract
Metastasis is the major cause of cancer-related mortality. Metastasis is a process through which cancer spreads from its initial location to other sections of the body. Cancer cells' epithelial-mesenchymal transition (EMT), anoikis resistance, cell migration, and angiogenesis are all well-known steps in this process. Investigating the molecular processes that govern cancer meta [...] Read more

Journal Article
Comprehensive analyses reveal molecular and clinical characteristics of RNA modification writers across 32 cancer types
by Jiayu Ding , Hao Shen , Jiaying Ji , Jiaxing Li , Wenbin Kuang , Zhongrui Shi , Dawei Wang , Yuanyuan Chen , Didi Wan , Xiao Wang  and  Peng Yang
Abstract
Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have pr [...] Read more
Hit Affiliation:
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China

Review
Overcoming the challenge: cell-penetrating peptides and membrane permeability
by Yuan Gu , Long Wu , Yasir Hameed  and  Mohsen Nabi-Afjadi
Abstract
Cell-penetrating peptides (CPPs) have emerged as a promising strategy for enhancing the membrane permeability of bioactive molecules, particularly in the treatment of central nervous system diseases. CPPs possess the ability to deliver a diverse array of bioactive molecules into cells using either covalent or non-covalent approaches, with a preference for non-covalent methods t [...] Read more

Journal Article
Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications
by Xingru Zhao , Qi An  and  Jingwen Cai
Abstract
Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydro [...] Read more

Journal Article
LTBP1 promotes the progression of triple negative breast cancer via activating the RhoA/ROCK signaling pathway
by Jingcheng Zhang , Hong Deng  and  Jun Wang
Abstract
The latent transforming growth factor-beta (TGF-β) binding protein 1 (LTBP1) has been implicated in various cellular processes, but its role in triple-negative breast cancer (TNBC) remains unclear. In this study, we investigated the impact of LTBP1 on TNBC progression and its underlying mechanisms. Analysis of online datasets revealed elevated LTBP1 mRNA expression in brea [...] Read more

Review
The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements
by Yi Wu , Yanqi Li , Tong Wu  and  Hongmei Yang
Abstract
Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom of cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles in pathophysiological mechanisms in cancer, which is attracting great attention. However, there are still controversies about whether [...] Read more

Journal Article
Polymers containing natural plant phenolic compounds for peripheral nerve injury
by Tong Zheng , Shuoke Qiu , Lei Li , Binglong Li  and  Meng Zhang
Abstract
Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit trea [...] Read more